Right Ventricular Outflow Tract Melanoma Diagnosed Using a Transfemoral Biopsy Through a Shortened Jr-4 Guiding Catheter

An 83-year-old man, known for having a melanoma of the right eye choroid, treated with proton therapy in 1998, was referred 21 years later for investigation of an asymptomatic heart murmur. Transthoracic echocardiography showed a 50 (cid:1) 22 mm mass in the right ventricular out ﬂ ow tract, with moderate obstruction and a mean/maximum gradient of 16/ 23 mm Hg (Fig. 1A). Magnetic resonance imaging con ﬁ rmed the presence of a pediculated hypervascular, mobile, sub-pulmonary mass originating from the upper interventricular septum (Fig. 1, B and C). Hyperintense character on T1 suggested the presence of melanin. Thoraco-abdominal computed tomography revealed a left upper-lobe pulmonary nodule, a right lower-lobe nodule, and a retroperitoneal mass, all hypermetabolic on 18 F-ﬂ uorodeoxyglucose e positron-emission tomography. Coronary angiography showed vascularization of the mass by 2 septal arteries (Fig. 1D). A multidisciplinary panel recommended biopsy of the cardiac mass, considering its accessibility. The ﬂ uoroscopy-guided procedure was performed through right internal jugular vein access (Fig. 1E) and was complicated by pericardial effusion requiring pericardiocentesis secondary to a highly mobile mass and lack of support. Histology remained inconclusive. Another biopsy guided by ﬂ uoroscopy and transthoracic echocardiography, through femoral access, was performed

catheter was shortened using a 7-F terumo sheath in order to use the bioptome (Fig. 1F) and collect 4 pieces of the mass (Fig. 1, G and H).The femoral approach with the shortened JR-4 guide catheter allowed greater stability and facilitated manipulation and orientation of the bioptome to the mass without complications.
Histology analysis revealed epithelioid cells with prominent nucleoli and pigmented cytoplasm (Fig. 2A).The presence of melan A was confirmed by immunostaining (Fig. 2B), which is consistent with cardiac metastasis from a malignant melanoma.Sequencing of a 400-gene panel showed a GNAQ G464V and a rare BRAF Q209L mutation, compatible with recurrence of a uveal melanoma.Due to the obstructive nature of the mass, without any reasonable surgical option or proven systemic therapy, a targeted palliative debulking radiotherapy consisting of 48 Gy was completed.At 1 month, a computed tomography scan showed stability of the cardiac mass (Fig. 2, C and D) but progression of other lesions in number and size.The patient died 3 years later.
Even if the combination of clinical and multimodal imaging approaches can avoid a biopsy, histopathologic analysis CJC Open 5 (2023) 904e906

Novel Teaching Points
Histopathologic analysis obtained by a biopsy is the gold standard for the diagnosis of a cardiac mass.Biopsy via femoral access is an option when the traditional jugular vein access presents difficulties because of the angle, location, or mobility of the mass.Guidance by echocardiography can increase biopsy success rates and maximize its diagnostic yield.Secondary cardiac tumours are more common than primary ones and are associated with a particularly poor prognosis.
obtained by it remains the gold standard for the diagnosis of cardiac masses.Secondary cardiac tumours are 40 times more common than primary tumours. 1 They confer a particularly poor prognosis (1-year mortality > 50%), generally requiring palliative treatment. 2In melanoma, cardiac metastasis occurs in < 2% of patients with metastatic disease. 3Uveal melanomas are a rare subtype that responds less to immunotherapy, with response rates between 3% and 8%.Dual immunotherapy with ipilimumab and nivolumab has shown greater response but with significant toxicity. 4In addition, the patient had an atypical BRAF mutation associated with decreased sensitivity to dual anti-MEK and anti-BRAF inhibition.Given the lack of proven systemic therapies, the approach consisted of clinical and radiologic follow-up in this asymptomatic patient.

Ethics Statement
The research reported has adhered to the relevant ethical guidelines.

Patient Consent
The authors confirm that patient consent is not applicable to this article.This is a retrospective case report using de-

Figure 1 .
Figure 1.(A) Transthoracic echocardiography (TTE), end-diastolic parasternal long-axis view, arrow indicating right ventricular mass.(B) Axial shortaxis cine magnetic resonance imaging, arrow indicating right ventricular outflow tract (RVOT) mass.(C) Sagittal cine magnetic resonance imaging, right ventricular outflow, arrow indicating RVOT mass.(D) Coronary angiography, left anterior oblique cranial, arrows indicating vascularization of the mass by 2 septal branches.(E) Angiography of the mass through a right internal jugular access, arrow indicating the RVOT pediculated mass.(F) 8-F (blue) 100-cm-long right coronary Judkins 4 Launcher (Medtronic) guiding catheter, which was shortened by cutting approximately 15 cm (shown by 1).We reconnected the distal and proximal portions of the guiding catheter using the distal part of a 7-F (orange) Terumo (Tokyo, Japan) introducer sheath Therefore, the proximal portion of the introducer sheath with the valve was cut, (indicated by asterisk).The dilator (indicated by double asterisk) of the introducer sheath was used to facilitate the reconnection of the 2 pieces of the guiding catheter using a portion of the introducer sheath (X).(G) Biopsy guided by fluoroscopy and TTE through a right femoral access using an 8-F regular 100-cm-long guiding catheter, which was initially too long to open a 104-cm-long Cordis bioptome.(H) TTE, parasternal short-axis view, arrow indicating the bioptome (hyperechoic) collecting pieces of the RVOT mass.AV, aortic valve; RA, right atrium; RV, right ventricle.